To completely fuck-up in your profession. A butt fumble (n) or to butt fumble (v).
Example 1: Did you see Mark Sanchez, the Jets quarterback, run into the ass of his own lineman and lose the football? That butt fumble has been voted the worst of the worst sports mistakes for two months straight now.
Surgeon A: “I can’t believe I amputated the wrong leg of that patient."
Surgeon B: “Man, you totally butt fumbled that operation. You're probably going to get your license suspended."
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