Top Definition
the aggravated state a man gets in when he has not received dome for an extended period of time
Quentin: holy fuck im about to kill someone
Dan: looks like you have dome syndrome. you just need some dome dude, chill out
#pissed off #homocidal #need dome #blow me #eat ass
door Barndon A. 22 oktober 2005
The elitist inbred offspring of Notre Dame alumni.
ND Student 1: "Why is George Walker (8th generation legacy) a student here? He barely communicates in monosyllabic grunts. I thought you had to be a smart overachiever or at least a gifted athlete to get into the University of Notre Dame!"

ND Student 2: "Dude, He has dome syndrome."
#university of notre dame #down syndrome #legacy #inbreeding #inbred #mutant #red neck #incest #indiana #south bend #saint mary's #smc #sluttle #notre dame #du lac
door BKitty (class of 2012) 22 oktober 2008
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