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1.
The growth of an inflammed, festered, and bloody hemorrhoid that creates a groove-like affect in your feces.
Dave, don't do it. Jeff has an ass knuckle, that's not going to be fun.
door Sean Piner 30 september 2006
 
2.
Someone who is clueless or stupid.
"Dude the new guy is such a dumbass!

"for real, he's a total friggin' ass-knuckle!
door Skin bone 21 mei 2011