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1.
Mafia term A good solid man business man. not one to bullshit, can be trusted. Will do anything needed for his family.
AL: Should I worry that donnI is going to jack me on this deal?

Mikey: Donnie is a stand up guy, I trust him with my life.
door icedoutgear.com Dave 6 april 2006
 
2.
Meaning

A loyal and reliable friend.

Origin

The allusion is to someone who would be prepared to stand up and fight on your side if called on, i.e. one who, in the words of the earlier (late 19th century) phrase, would 'stand up and be counted'.

The phrase is American. The earliest citation is in the Pennsylvania newspaper The Charleroi Mail, April 1935:
"But he seems to be a stand up guy and loyalty, with him, seems to be less a virtue than obsession."
door Dixon St. Grottlesex. 5 november 2009
 
3.
trustworthy fella you can count on in any predicament
Oh course James Bridges can be counted on if you are in a bind. After all, he IS a stand up guy.
door F0ShizzleNizzle 14 december 2010
 
4.
What a quadriplegic isn't.
*John sees quadriplegic commit good deed*
John: Hey bud, you're a real stand-up guy!
Quadriplegic: ...
door eyyyy guy 15 november 2010
 
5.
Someone who won't give up anything under interrogation.
Standing up to questioning.
Cop: Awright asshole, where'd you get that illegal substance?
Guy: I dunno what that is or how it got there. Never seen it before.
Cop: Oh yeah? We're gonna lock up up and throw away the key if you don't tell us where you got that stuff.
Guy: I don't know NOTHIN' about it!

Dig it, you are a stand up guy!
door Straight Shooter 1 oktober 2007