Meaning something is REALLY cool. And by playing with the double meaning of the word "sick" (along with "REALLY cool", the original meaning simply meant "unwell", etc) , emphasises how cool the thing in which is "sick" really is.

Sicker than the disease AIDS apparently.

That's what creates the "REALLY" presence in front of "cool".
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Damian: "You should come check out the 30 pizzas I dumpstered from Little Caesers that I have in my car."

Rakeem: "Holy shit man. That's fuckin' sicker than AIDS bro!"
door From the bowels of Tasmania 22 april 2009
5 Words related to Sicker than AIDS

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