Top Definition
verb. To screw up something or everything by your inexplicable actions as every Mark Ruffalo character manages to do.
Wow, he really ruffaloed his marriage by sleeping with his secretary.
I don't want to pull a ruffalo here, so I'm just going to go home to sleep.
I'm trying not to ruffalo this relationship with my neuroses.
door Terry Prescott 17 juli 2009

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