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64.
The palest girl around town who falls for the type of guy who lingers around the gay bar and chats it up the nocturnal citizens of the under world. A Melissa will usually sound exactly like kermit the frog.
Brad: hey marven, whos that that chick whose whiter than sour cream? I'd like to put gas into that car if you catch my drift!

Marven: Thats Melissa, i tried to watch "Everybody loves Raymond" but i couldn't tell who was talking.
door cramped thighs 27 december 2011
 
65.
Acronym: MELISSA: My Entire Life Is Spent Striving Ahead
A very driven woman in her 20s or 30s eg that new girl is a real Melissa.
door socialwatcher 19 mei 2007
 
66.
Overachiever, split ends, wears the same clothes every day. Obnoxious, and rude. Thinks she is better than everyone else and feels the need to hit on your man. I give her props for not switching schools when everyone found out about what she did to her ex-boyfriend.
Lexi: Really, Melissa? Stop hitting on my man.

Mariah: Melissa, you seriously need to stop trying so hard, no man will ever love you.

Alex: Dude, why'd you break up with Melissa? She's so good at sports
Josh: Didn't you hear that Melissa took a shit on me when we dated? I was like bye bye!
door hmmthatsmeeeeee 11 december 2011
 
67.
Someone who constantly talks shit. This person litterally only opens her mouth to talk all kinds of mad rediculous shit...even when she isnt involved in the conversation she will still interject in order to talk shit.
boy- so bro wanna chill or something

random girl (melissa)- FAGGOT

boy- Shut up Melissa no one even likes you
door OHgreat1 4 januari 2012
 
68.
Someone who is really blunt, but will tell you the truth, no matter what the circumstances. Someone who likes to go shopping, eat a lot, sleep and is kind of promiscuous but doesn't care if anyone calls her a whore. Melissa's are cool, nice, fun, honest,kinda whorish and a non conformist.
Guy#1: Dude! Did you make out with that girl at the party last night?
Guy#2: Hell yeah. She was pretty easy.
Guy#1: What's her name?
Guy#2: Melissa.
Guy#1: Figures.
Guy#2: She's cool though.
door LifesucksbigTyme 13 april 2009
 
69.
The kind of girl that lies for attention.

Don't trust this girl, she'll tell you she has cancer and she'll tell you she's pregnant just to get her own way. She's also a complete jealous bitch of anyone who goes near her ex boyfriend. Also the worst follower in the world of dental hygiene. Bitch got clagnuts for teeth, yo.
OMG! Melissa is such a bitch.

Have you seen Melissa's teeth?! Ewwww.

Melissa got CLAGNUTS in her mouth, bro.
door Don'ttrustcuzthehowon'ttrustme 3 december 2011
 
70.
a girl who will usually give blow jobs and do alot of kinky stuff

such as suck your dick with food on it. most melissa are bigger girls that are dieing for atention and will fuck you for it
melissa: hey johnny
johnny: ehh
melissa: wanna fuck
johnny: hell yeah
melissa after sex: wanna go out
johnny: what who are you did you drug me
door thatoneguyyoublew 7 juni 2011