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1.
The antagonist on the animated Hanna-Barbera series, The Smurfs. All he wanted to do was eat the blue guys and turn them into gold, but alas, he never could.

He lived in a rackety hovel that had seen better days with his orange cat Azrael and his nephew/apprentice Scruple. Despite being the villian, he was one of the most hilarious characters on the show.

Also reffered to as "Garglesmell" by Hogatha.
Gargamel scared the shit out of Vanity Smurf.
door Gwen Stefani Grrl 11 januari 2004
 
2.
Shitty or weak.
"That shit is gargamels, son!"
door ready2ruck 10 maart 2003
 
3.
A crotchety old wizard who lives in a ramshackled stone building in the woods with a cat and occasionally a little boy who is always trying to hunt down and eat little blue creatures called smurfs because he's too lazy to walk to town and go to the deli for a pastrami on rye.
Gargamel hungry. Need smurfs...
door Zero X. Diamond 28 maart 2003
 
4.
a judeah-imperialist-capitalist wizard who lives in a hobble with his orange cat and skruple his apprentice and hunts down those commie bastard smurfs and trys to boil them into gold or eat them but the smurfs always outsmart him
smurfs - after them skruple
door Brother_Number_One 9 juli 2003
 
5.
Highly unattractive human being. We're talking 5 star ugly here. Rides the bus a.k.a. The Gargamel Express. Natural habitat = Walmart.
Sena: Some greasy haired, pajama pants wearing freak on the bus asked me out on a date to Walmart! Can you believe that? Joey: Gargamel... er what?
door Agent00Devon 8 maart 2012
 
6.
One who indulges in a long night of hard drink, I mean Martin Luther King Jr. Status, and then pursues one of the lady folk in an intimate manner usually characterized by much grabbing of her body parts and gibberish being spoken. The night for this person usually ends with him in the Penn State shower room horse playing with the young boys.
Sean was straight gargameling last night which is why he's now donating 10,000 dollars to the 2nd mile charity.
door Chickin Fingaz 20 november 2011
 
7.
A guy who tucks his male genitalia between his legs to see how he'd look if he was a woman.
Silence of the Lamb's "Buffalo Bill" is a gargamel for stuffing the boys between his legs and admires himself.
door paul-e-wog 23 mei 2008