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1.
1.When somebody is Bitching at you for no good reason or nagging at you to do something you don't want to do.
Shit Bitch, quit Busting my Balls about me being out all night with my friends.
door Mojo Maniac 10 juli 2008
 
2.
An exclamation used, when the user is pissed off at a character in a Video Game.
"You're busting my balls Mario!"
door Bik Valbordo 21 november 2007